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Discoloration - an overview of depigmenting substances

Review of active substances with depigmentation and brightening properties

Discolorations, also known as pigmentation disorders, are caused by various factors. Hormonal changes, skin exposure to the sun, photo-aging and irritation are the most common ones.

Depending on the cause and type of discoloration, care for skin exposed to changes in pigmentation should be effectively planned. An important role in this topic is played by the cause of skin changes, i.e. the selection of substances standardized for a specific effect on the skin. For this, it will be necessary to review depigmentation and brightening substances.


Darkout™ is an extract obtained from the bulbs of an African plant called Hypoxis Rooperi and Caesalpinia Spinosa - an African tree popularly known as Tara. This modern preparation, of organic origin, effectively brightens, and its effectiveness has been confirmed by in vitro tests. It allows you to achieve a light, even and radiant skin tone, reducing visible and age-related dark spots, discolorations, freckles and other skin pigmentation disorders.

This ideal active substance with a brightening effect reduces the synthesis of melanin and increases the synthesis of collagen. It is a safe alternative to kojic acid, which is a by-product of the fermentation of rice used in the production of sake - although it effectively inhibits melanin production, it can cause irritation and contact dermatitis.

Darkout™ is an active ingredient of natural origin that evens out skin color. It helps brighten the skin and make it more radiant. Cosmetics containing this substance improve the uniformity of skin color and help reduce aging spots, freckles and discoloration.


Effect confirmed by in vitro tests:

  • brightening: reduction of tyrosine hydroxylase activity (54%) and dopa-oxygenase (53%), reduction of melanin synthesis (51%), inhibition of tyrosinase expression;

  • antioxidant: inhibition of reactive oxygen species in human fibroblasts (50%);

  • anti-aging: increase in the synthesis of collagen I (242%) and collagen III (186%). It is a derivative of urea, has a soothing effect and accelerates the healing process of damaged epidermis.


Products containing Darkout™

Liposom white 

Liposome white - brightening and whitening complex - a liposomal preparation combining strong whitening ingredients, i.e. arbutin (bearberry) and antioxidants, giving a strong skin brightening effect. Safely stops skin pigmentation by reducing the activation and activity of tyrosinase, reduces melanin synthesis and provides a luminous skin tone. No preservatives.
Bearberry leaves contain arbutin, a natural derivative of hydroquinone. The source material is grown without pesticides.

  •      A strong inhibitor of tyrosinase activity

  •      More stable and safe than hydroquinone

  •      It allows for long-term use

  •      The activity is not related to tyrosinase toxicity

Natural Reduced Glutathione:

  •      One of the strongest antioxidants in the skin

  •      Stops tyrosinase activity thanks to its reducing properties

  •      Its amount decreases with age


Glutathione is called the most import

ant antioxidant in the human body. This compound is a tripeptide consisting of amino acid residues of compounds such as cysteine, glycine and glutamic acid. It is worth mentioning that glutathione is a substance that occurs naturally in all plant and animal organisms. The described tripeptide is primarily an antioxidant. Therefore, its main task is to destroy harmful free radicals and remove heavy metals such as arsenic, lead and mercury, which enter the body from food and air. Glutathione also delays the aging process.

Vitamin C palmitate:
The optimal form of vitamin C for local use

  • It has antioxidant, anti-aging and whitening properties

  • It can also lighten existing dark spots

Features of the complex:

  • Safe inhibition of the pigmentation process

  • Reduction in melanin synthesis

  • Brightening the skin tone
  • Targeted action thanks to the liposomal form

  • Protective properties thanks to the high content of antioxidants

  • Perfect for daily care


Cywhite G

Cywhite G is a substance obtained from the algae Cystoseira tamariscifolia. It has a brightening, depigmenting and regenerating effect on the epidermis. Protects against the harmful effects of UV radiation.
Cywhite G acts on the production of melanin, the maturation of melanosomes, as well as their destruction, benefiting the basic skin pigmentation and its uniformity. It slows down the transfer of melanosomes to keratinocytes.


Cywhite G works in 3 steps: Before, during and after melanin synthesis to reduce skin pigmentation.

  1. Within keratinocytes, inhibition of melanogenesis activation

  2. Within melanocytes, inhibition of melanogenesis
  3. Within keratinocytes, reducing the amount of pigments


  1. Brightening effect + pigment spots

  2. Renewing and brightening effect

  3. Brightens and protects against radiation



  1. Reduction of factors involved in the activation of melanogenesis

  2. Reduction of factors involved in melanosome maturation

  3. Degradation of melanosomes
  4. Decrease in melanin synthesis

  5. Brightening the skin and improving its luminosity



  1. Lightening pigmentation disorders

  2. Reduction of skin heterogeneity

  3. Reducing the visibility of pigmentation spots

Products containing Cywhite G

Azelaic acid

Azelaic acid is an organic compound from the group of dicarboxylic acids with proven antibacterial, anti-inflammatory and slightly exfoliating properties. It is recommended for people with rosacea and acne vulgaris, atopic dermatitis and discoloration. It inhibits the growth and excessive activity of melanocytes. Discoloration is treated by inhibiting DNA synthesis and cellular respiration of melanocytes.

Azelaic acid is a year-round product, but when using acid treatments, it is always recommended to use high SPF protection.


Azeloglycine - an active substance that combines the properties of two ingredients: azelaic acid and the amino acid glycine.

Azeloglycine is used to treat increased skin pigmentation resulting from increased activity or excessive action of melanocytes. This includes malanoderma, malignant freckles and photochemical hyperpigmentation. It is considered a competitive and reversible inhibitor of tyrosinase, which is a key enzyme in elanogenesis.


Products with azeloglycine and azelaic acid

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